There were characters in The Hornet's Nest who migrated from Philadelphia to Orange County, North Carolina, in 1765. My Trousdales were in Orange County in the 1700's and probably lived in Pennsylvania before moving there, somewhat paralleling the lives of the fictional Pratt brothers.
The western North Carolina farmers in the area of Orange County chafed at the colony's governance, particularly the power wielded by Governor Tryon and Edmund Fanning (Fanning was described as someone who was supposed to be "just the register of deeds, but [made] all the final decisions at the courthouse..".
A deed involving John Trousdale and James Trousdale mentioned the Haw river and Great Alamance:
Whereas John Trousdale, some time ago having purchased a tract of land from Mary E. McCulloch, being the tract in the fork of Haw river and Great Alamance, and containing six hundred and twenty acres... .
"....the Stockards, the Trowsdales, the Freelands, the Albrights....".
A small group of politically active men with grievances formed the Sandy Creek Association. One of the characters, Henry Pratt, who was a member of the association, "joined up with some other men, both in Orange and other western counties, to form a group known as the Regulators."
William Trousdale and John Trousdale both signed a document vouching for the character of a Regulator who was in trouble, according to this document (and this site).
When the government's militia confronted the Regulators, there was trouble -- big trouble, culminating in the Battle of Alamance.
My ancestor, Alexander Trousdale, moved from Orange County, North Carolina to Montgomery County, Tennessee.